Journal article
Associations of Height with the Risks of Colorectal and Endometrial Cancer in Persons with Lynch Syndrome
JGM Brouwer, PA Newcomb, TM Bisseling, JC Figueiredo, JL Hopper, MA Jenkins, JJ Koornstra, NM Lindor, HFA Vasen, AK Win, E Kampman, FJB Van Duijnhoven
American Journal of Epidemiology | OXFORD UNIV PRESS INC | Published : 2021
DOI: 10.1093/aje/kwaa175
Abstract
People with Lynch syndrome (LS), who carry a pathogenic mutation in a DNA mismatch repair gene, have increased risks of colorectal cancer (CRC) and endometrial cancer (EC). A high reported variability in cancer risk suggests the existence of factors that modify cancer risk for persons with LS. We aimed to investigate the associations between height and CRC and EC risk for persons with LS using data from 2 large studies. Information on 1,115 men and 1,553 women with LS from the Colon Cancer Family Registry (1998-2007) and the GEOLynch Cohort Study (2006-2017) was harmonized. We used weighted Cox proportional hazards regression models with age on the time axis to estimate adjusted hazard ratio..
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Awarded by Wereld Kanker Onderzoek Fonds Netherlands as part of the World Cancer Research Fund International grant program
Awarded by National Cancer Institute, US National Institutes of Health
Funding Acknowledgements
The GEOLynch Cohort Study is supported by the Wereld Kanker Onderzoek Fonds Netherlands as part of the World Cancer Research Fund International grant program (grant 2014/1184). The Colon Cancer Family Registry is supported in part by funding from the National Cancer Institute, US National Institutes of Health (award U01CA167551). Support for case ascertainment was provided in part by the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) Program and 5 US state cancer registries (Arizona, Colorado, Minnesota, North Carolina, and New Hampshire) and by the Victorian Cancer Registry (Melbourne, Victoria, Australia) and the Ontario Cancer Registry (Toronto, Ontario, Canada).